Nuclear Factor-κB is a Prime Candidate for the Diagnosis and Control of Inflammatory Cardiovascular Disease

Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is responsible for the regulation genes involved in inflammation and immune responses. NF-κB may play an important role cardiovascular diseases (CVDs), atherosclerosis diabetes. Several therapeutic agents used treatment CVDs diabetes, such as pimobendan sodium–glucose cotransporter 2 inhibitors, exert anti-inflammatory effects by inhibiting activation; therapy have beneficial pharmacological natural compounds inhibit NF-κB, these alone or combination be to treat various inflammatory diseases. Immunoglobulin-free light chains could surrogate biomarkers activation useful evaluating efficacy agents. This review discusses recent advances our understanding how signalling pathway controls inflammation, metabolism immunity, improved knowledge pathways lead better diagnostics therapeutics human